pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays (2017)

, ,

K Ehrlich, A Kufcsák, S McAughtrie, H Fleming, N Krstajic, C J Campbell, R K Henderson, K Dhaliwal, R R Thomson, M G Tanner.


Read the article here

Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement. In this manner, pH sensing through a multimode fibre at a low excitation power that is safe for future in vivo applications, with short acquisition times (10 or 60 s), is demonstrated. A measurement precision of ± 0.07 pH units is thus achieved.


Posted on

June 5, 2023

Skip to content