Models for Pre-clinical Testing
We have developed several translationally relevant model systems optimised for clinical tractability.
- Freshly-excised human lung tissues (from non-small cell lung cancer and IPF),
- Human lungs (obtained a UK wide consortium and deemed not fit for transplant) which can be ventilated and perfused on an ex-vivo lung perfusion system (EVLP)
- Tissue derived from cull-stock animals (therefore in keeping with the principles of the 3 R’s in animal research).
These models range from single cell, organoid, precision-cut lung slices to whole human lungs. This work also enables discovery work for tractable targets and for imaging in humans