A matrix metalloproteinase activation probe for painting human tumours (2020).

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Mills B, Norberg D, Dhaliwal K, Akram AR, Bradley M, Megia-Fernandez A.


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A probe that allows specific ‘painting’ of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.



Posted on

June 5, 2023

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